CRAVE CONTROL+ is 4+ NUTRITION hunger-breaker, made specifically to avoid excess food consumption and facilitate weight loss.

The synergy of its components and the completeness of its formulation make this product effective and pleasant to take. HOWARU® B420 for the first time in Italy from 4+ NUTRITION in order to offer the most innovative ingredient now in market! HOWARU® B420 contains 10 billion CFU Bifidobacterium lactis (as B420). In a clinical study in 2016, has been proven the effectiveness of Bifidobacterium lactis in helping reduce waist circumference in overweight adults. It has also been demonstrated in vitro to increase epithelial integrity. The randomized, double-blind, controlled study was conducted in 225 healthy adults and took place over the course of six months with a one-month follow-up. Participants’ body mass index (BMI) values were between 28-34.9, and thus, were considered overweight. The subjects were divided into four groups, with each group receiving one of four daily regiments

  1. A placebo consisting of 12g microcrystalline cellulose;
  2. 12g of polydextrose ingredient, a specialty carbohydrate with prebiotic properties and widely recognized as a fiber;
  3.  1010 CFU/day of Bifidobacterium lactis B420 administered with 12g dose of microcrystalline cellulose;
  4.  1010 CFU/day of Bifidobacterium lactis B420 administered with 12g of fiber.

The subjects’ blood was drawn once at baseline, then at two, four, and six months, and finally once during a follow-up visit. At each visit, researchers measured body fat with a dual-energy X-ray absorptiometry (DEXA) scan, and recorder body fat mass and lean body mass. In addition, researchers measured other obesity-related outcomes, including body weight and waist and hip circumference, with calibrated weighing scales and tape measures, respectively. After six months of study, the researchers observed notable differences between the groups that received HOWARU® B420 in either form and the groups that did not. HOWARU® B420 (plus fiber) was found to reduce body mass by 4.5% and waist circumference by once inch versus the placebo group, with an average difference of 1.4kg in total body fat between those groups. In addition, the researchers found that HOWARU® B420 alone resulted in a reduction of body weight, whereas B420 plus the fiber resulted in a reduction of body fat mass counterbalanced with an increase in lean muscle mass. According to the study authors, the results indicate that HOWARU® B420 can help to control body fat mass, reduce waist circumference, and reduce food intake.


Due to the results obtained from the association of the probiotic HOWARU® B420 with a fiber, 4+ NUTRITION decided to use in the product CRAVE CONTROL 4 HER+, the oligofructose Orafti P95. After fermentation in the intestine, the Orafti P95 fiber triggers a cascade of events that promote the reduction of food intake, and therefore more calories. Several studies have demonstrated its ability to reduce levels of ghrelin (a hormone that stimulates appetite) and increase anorexigenic hormones such as PPY(Fig.1;.Jill A Parnell and Raylene A Reimer, 2009; Norlida M. Dauda et al., 2014).

The HOWARU® B420 probiotic promotes the synthesis of short-chain fatty acids (SCFA) which are likely to reduce the ghrelin synthesis. In the intestine, they can stimulate the release of anorexigenic hormones, such as GLP-1 and PYY. Through these mechanisms, Orafti P95 and HOWARU® B420, reduce the feeling of needing food, help reduce fat mass and contribute to weight loss.

SATIEREAL consists of Saffron, known since antiquity for its many positive actions. SATIEREAL is attributed the hunger-breaker property, capable of controlling and reducing compulsive hunger. It can counteract the feeling of appetite related to stress, increasing the feeling of fullness and therefore reducing the amount of food ingested. It is very useful when paired with a low-calorie diet for those who want to lose weight. Its use even during seasonal changes is particularly interesting. The different temperatures we are exposed to often lead to a change in eating habits too, which could cause an unwanted weight gain. Taking SATIEREAL, you can address this change with extra support. In support of the SATIEREAL action, griffonia (Griffonia simplicifolia), particularly useful to combat emotional eating. In fact, griffonia is an excellent source of 5 hydroxytryptophan (5-HTP), forerunner of the much-loved serotonin. Known for its ability to promote good mood, serotonin is also useful as a support in weight loss. In fact, it manages to decrease the compulsive search for carbohydrates due to the sensation of generalized wellness it promotes. It increases the feeling of fullness and reduces appetite, without altering the mood.

Download HOWARU® B420 brochure

Add 1 sachet (12 g) in 200 ml of water and take twice a day, preferably before each of the two main meals.
Ingredients - Nutritional information
Orafti® P95 (fructo-oligosaccharides), bulking agent: sorbitol; acidifiers: malic acid, citric acid; colour: beetroot red; flavourings, anti-caking agent: silicon dioxide; thickener: xanthan gum; Satiereal® [saffron (Crocus sativus L.) stigmata d.e. tit. 0,3% safranal], griffonia (Griffonia simplicifolia (DC.) Baill.) seed d.e. tit. 25% 5-hydroxy tryptophan, sweetener: sucralose; HOWARU® Shape (Bifidobacterium lactis B420TM SD6685).
Media Analysis
For serving2 sachets=24g
Calories46 Kcal
Carbohydrates1,8 g
- of which Sugars0,9 g
Fat0 g
- of which Saturates0 g
Salt0 g
Fiber19 g
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