CRAVE CONTROL 4HIM+ is 4+ NUTRITION hunger-breaker, made specifically to avoid excess food consumption and facilitate weight loss.

The synergy of its components and the completeness of its formulation make this product effective and pleasant to take. HOWARU® B420 for the first time in Italy from 4+ NUTRITION in order to offer the most innovative ingredient now in market! HOWARU® B420 contains 10 billion CFU Bifidobacterium lactis (as B420). In a clinical study in 2016, has been proven the effectiveness of Bifidobacterium lactis in helping reduce waist circumference in overweight adults. It has also been demonstrated in vitro to increase epithelial integrity. The randomized, double-blind, controlled study was conducted in 225 healthy adults and took place over the course of six months with a one-month follow-up. Participants’ body mass index (BMI) values were between 28-34.9, and thus, were considered overweight. The subjects were divided into four groups, with each group receiving one of four daily regiments

  1. . A placebo consisting of 12g microcrystalline cellulose;
  2.  12g of polydextrose ingredient, a specialty carbohydrate with prebiotic properties and widely recognized as a fiber;
  3.  1010 CFU/day of Bifidobacterium lactis B420 administered with 12g dose of microcrystalline cellulose;
  4. 1010 CFU/day of Bifidobacterium lactis B420 administered with 12g of fiber.

The subjects’ blood was drawn once at baseline, then at two, four, and six months, and finally once during a follow-up visit. At each visit, researchers measured body fat with a dual-energy X-ray absorptiometry (DEXA) scan, and recorder body fat mass and lean body mass. In addition, researchers measured other obesity-related outcomes, including body weight and waist and hip circumference, with calibrated weighing scales and tape measures, respectively. After six months of study, the researchers observed notable differences between the groups that received HOWARU® B420 in either form and the groups that did not. HOWARU® B420 (plus fiber) was found to reduce body mass by 4.5% and waist circumference by once inch versus the placebo group, with an average difference of 1.4kg in total body fat between those groups. In addition, the researchers found that HOWARU® B420 alone resulted in a reduction of body weight, whereas B420 plus the fiber resulted in a reduction of body fat mass counterbalanced with an increase in lean muscle mass. According to the study authors, the results indicate that HOWARU® B420 can help to control body fat mass, reduce waist circumference, and reduce food intake.


Due to the results obtained from the association of the probiotic HOWARU® B420 with a fiber, 4+ NUTRITION decided to use in the product CRAVE CONTROL 4 HIM+, the oligofructose Orafti P95. After fermentation in the intestine, the Orafti P95 fiber triggers a cascade of events that promote the reduction of food intake, and therefore more calories. Several studies have demonstrated its ability to reduce levels of ghrelin (a hormone that stimulates appetite) and increase anorexigenic hormones such as PPY(Fig.1;.Jill A Parnell and Raylene A Reimer, 2009; Norlida M. Dauda et al., 2014).

The HOWARU® B420 probiotic promotes the synthesis of short-chain fatty acids (SCFA) which are likely to reduce the ghrelin synthesis. In the intestine, they can stimulate the release of anorexigenic hormones, such as GLP-1 and PYY. Through these mechanisms, Orafti P95 and HOWARU® B420, reduce the feeling of needing food, help reduce fat mass and contribute to weight loss.

In addition, CRAVE CONTROL 4 HIM+ contains Garcinia cambogia Citrin®K, a patented form of garcinia, characterized by the ability to decrease appetite and help to lose weight. In fact, Citrin®K, is able to suppress hunger, inhibiting cytoplasmic lyase citrate and increasing lipid metabolism in obese subjects. Effects obtained thanks to the mechanism of action of the potassium salt of hydroxycitric acid, contained in the fruit of Garcinia. Responsible for the characteristics of garcinia, hydroxycitric acid:

- Promotes inhibition of fatty acid synthesis by inhibiting the enzyme Citrate lyase;

- Promotes the oxidation of fatty acids by inhibiting the synthesis of Malonyl CoA;

- Promotes the sense of satiety since it induces gluconeogenesis and glycogenesis due to the activation of beta oxidation.

Hence the slimming and hypolipidemic qualities of garcinia.

Download HOWARU® B420 brochure

Add 1 sachet (12 g) in 200 ml of water and take twice a day, preferably before each of the two main meals.
Ingredients - Nutritional information
Orafti® P95 (fructo-oligosaccharides), acidifier: citric acid; bulking agent: sorbitol; flavourings, Citrin® K [garcinia (Garcinia cambogia (Gaernt) Desr.) fruit d.e. tit. 50% hydroxy citric acid], anti-caking agent: silicon dioxide; thickener: xanthan gum; sweetener: sucralose; colour: carotenes; HOWARU® Shape (Bifidobacterium lactis B420TM SD6685)
Media Analysis
For serving2 sachets = 24 g
Calories48 Kcal
Protein0 g
Carbohydrates1.8 g
- of which Sugars1.0 g
Fat0 g
- of which Saturates0 g
Salt0 g
Fiber19 g
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