CYSTI+ is a cranberry-based supplement guaranteed by ExocyanTM, D-Mannose, the fructo-oligosaccharides of Orafti® P95 and vitamin C, for the well-being of the urinary tract.


1 in 2 women has been found to experience at least one episode of cystitis during her lifetime and that 10% of them suffer from relapsing UTI (urinary tract infection), with an increase directly proportional to their age. It has also been demonstrated that a supplement of cranberry (Vaccinium macrocarpori), can eliminate one of its main causes, the infection by Escherichia coli (E. coli), a bacterium responsible for 85% of infections. Normally present in the intestine, it is pathogenic when it reaches the urinary tract. Escherichia coli has a stick shape with the presence of fimbriae, filamentous appendages on the surface that make it capable of adhering to epithelial cells and colonize the tissues. The American cranberry can modify the structure of the fimbriae, rounding them up and making it impossible for the bacterium to adhere to the cell walls. In particular, cranberry is rich in type A proanthocyanidins (PAC), flavonoids that give the characteristic anti-adhesive properties to the fruit and have high antioxidant power. Unlike classical antibiotic therapy, the use of cranberry does not lead to bacterium resistance even if the intake is continued for prolonged periods. In CYSTI+ the dry extract of ExocyanTM cranberry, standardized in Type A PAC has been used with a 90% presence of total proanthocyanidins. NEXIRA uses the best analytical methods (BL-DMAC, Bate Smith (BS), European Pharmacopoeia and HPLC) to guarantee the ExocyanTM PACS-A content and the absolute purity of the product, completely free from any kind of adulteration.


In fact, ExocyanTM has Organic Certification, is solvent free (no solvent has been used) and GMO-FREE. In vitro tests show that ExocyanTM is more effective than other cranberry extracts. In fact, while at the end of the experiment the Escherichia coli in the ExocyanTM test tube had been eradicated and deposited at the bottom, the other samples showed E. coli biofilm in the liquid.

Another component with proven qualities against urinary tract infections is D-Mannose, a sugar that is poorly absorbed by the body and excreted through the urine as such. Its mechanism of action is complementary to that of ExocyanTM in that it also prevents the adhesion of the bacterium by binding to the E.coli fimbriae. The bacteria adhesive capacity to D-Mannose is also greater than that of the bladder cells, giving them the peculiarity of being able to detach not only the bacteria that have already damaged the wall but also those that have penetrated deep into it. It has also been shown that D-Mannose is able to bind to the toxins produced by the bacteria themselves to reach the inner layer of the mucosa. Thanks to these mechanisms, micro-organisms that do not adhere to the wall do not cause infection and are excreted through the urine avoiding contamination.

To prevent cystitis from becoming chronic, it is essential to restore the balance of the microbiota by taking probiotics and prebiotics. For this reason, the prebiotic Orafti® P95 has been added to CYSTI+. This is obtained from inulin by partial enzymatic hydrolysis, a process that occurs naturally in chicory roots at the end of the harvest. As a result, Orafti® P95 can boast being 100% natural. After enzymatic hydrolysis, a purification process is carried out in order to obtain a product of the highest quality. Following its intake, there is a significant increase in bifidobacteria and lactobacilli, which correspond to the positive bacteria in the intestinal tract. By increasing their presence, the amount of negative-acting bacteria decreases and struggles to perform any negative actions.

CYSTI+ completes its formula with vitamin C which is useful in many ways. In addition to its high antioxidant power to counteract the activity of free radicals, it also helps to increase normal immune defences. In addition, vitamin C promotes the creation of an acid environment at vaginal level, thus acidifying the urine and fighting the colonies of pathogens. Since the human body cannot produce this vitamin, it is necessary to take it through food or supplementation.

CYSTI+ has a complete, quickly effective formulation that does not cause bacterial resistance, is practical to use, with a pleasant taste and high quality of the ingredients used.

ExocyanTM is a trademark of Nexira.

Orafti® Oligofructose is a registered trademark of of BENEO.

How to use
Add 1 sachet (3 g) in 180 ml of water and take once a day.
Ingredients - Nutritional Info
Resistant dextrin (soluble fibre), D-mannose, ExocyanTM CRAN 10S - dry extract of Cranberry (Vaccinium macrocarpon Aiton) fruit std. 10% proanthocyanidins], Orafti® P95 (fructo-oligosaccharides), L-ascorbic acid (vitamin C), flavouring, anti-caking agent; silicon dioxide; sweetener: sucralose.

Additional Information

For serving 1 sachet (3 g)
Guaranà d.e. N/A
- of which caffeine N/A
Bitter orange extract N/A
- of wich synephrine N/A
Green Coffee Extract N/A
- of which chlorogenic acid N/A
Wakame seaweed d.e. N/A
- of which fucoxanthin N/A
Fructo-oligosaccharides 475 mg
D-Mannose 500 mg
Cranberry e.s. 500 mg
- of which pranhocyanidins 50 mg
Bodybalance ® (hydrolised collagen) N/A
Verisol® (hydrolised collagen) N/A
Sodium hyaluronate N/A
- of which hyaluronic acid N/A
trans-reveratrol Veri-teTM N/A
- of which trans-resveratrol N/A
Proβios matrix N/A
- of which nucleotides N/A
- of which B. subtilis Natto N/A
- of which B. coagulans N/A
Vitamin C 80 mg
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Available Product code CYSTI+


CYSTI+ is a cranberry-based supplement guaranteed by ExocyanTM, D-Mannose, the fructo-oligosaccharides of Orafti® P95 and vitamin C, for the well-being of the urinary tract.

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