A mono centric, placebo-controlled, randomized, double-blind, observational trial on 160 subjects at the Institute for Sports and Sports Science, University of Freiburg, Germany study, investigated the effect of orally administered Bioactive Collagen Peptides on young adults suffering from diagnosed activity-related knee joint pain. In the study a daily dosage of 5g Fortigel® or a placebo was orally administered for 12 duration of weeks. After 3,6 and 12 weeks changes in pain, stiffness and physical function were evaluated in the Fortigel® group using the Western Ontario McMaster Universities Index score (WOMAC). The results of the study clearly demonstrated the efficacy of 5g Fortigel® daily intake. After only 3 weeks of oral administration of the product a statistically significant improvement in pain, stiffness and physical function could be observed. Moreover, this positive effect of Fortigel® persisted and even more pronounced after 6 and 12 weeks of treatment. At the same time secondary treatments such as massage and physiotherapy have been substantially reduced. The increased mobility was accompanied by a statistically significantly reduction in stiffness and a clear pain relief. In more than 40% of all patients a complete pain reduction was achieved and in 70% a positive effect of the therapy could be demonstrated. 

An additional component of R-GEN JOINT + is ROXLOR's Cynatine® FLX that can stimulate the production of powerful antioxidants such as glutathione which defend the body from free radicals and tissues from damage. Cynatine ® FLX is a form of hydrolysed keratin, an important source of amino acids and mostly of sulphur, used for the construction and repair of many tissues. It has a fundamental role for structures such as hair and nails and equally for those of proteoglycans. Thanks to its participation in the formation of disulphide bridges, which link amino acids together, it helps determine the shape, properties and biological activity of proteins. Cynatine® FLX can supply cells with antioxidant directly, where they can act against ROS (Reactive Oxigen Species) and prevent oxidative damage.

Accordind to the clinical studies, Cynatine® FLX works in 4 ways:

1. Cynatine® FLX builds joint resilience: it supplies the key building blocks for joint repair. It provides the essential bioactive sulfur precursors that cells use to rebuild vital joint tissue, faster. It is the only joint mobility product that contains the building blocks needed for joint repair and remodeling of tissue.

2. Cynatine® FLX helps reduce inflammation: it suppresses the inflammatory mediators associated with degradation of the joints. A long term inflammation can lead to further erosion and assault on the joint. Reduced inflammation also means reduced pain and increased activity. 

3. Cynatine® FLX improves mobility: it activates highly potent antioxidants in the body. Unlike others antioxidants, Cynatine® FLX, is able to quench millions of free radicals with only one molecule of antioxidant agent. It also increases the production of SOD (superoxide dismutase) and of glutathione, a major antioxidant present in all parts of our organism. Research data indicates that ingested Cynatine® FLX helps to build the cell’s glutathione supply, resulting in an increase in glutathione-dependent peroxidase (GSH-PX), which is a primary defense against oxidative damage.

4.Cynatine® FLX protects the joint: it has intrinsic natural antioxidant activity. Even when it is not involved in rallying the body’s own defenses, Cynatine® FLX is still exerting a potent antioxidant effect. By increasing antioxidant defenses, Cynatine® FLX, can reduce the damage in joints caused by free radicals, which cause oxidative stress. This suppresses the inflammatory response which ultimately results in pain reduction and increased mobility. 

Finally, the formulation of R-GEN JOINT +, offers vitamin C. Powerful antioxidant and adjuvant of the immune system, it is a great ally for our body wellbeing.