R-GEN JOINT+ consists of Fortigel® B, Cynatine® FLX and vitamin C.
Fortigel® B is a compound of collagen peptides, obtained by enzymatic hydrolysis. Through this process the peptides are optimized to maximize the stimulation of the cells involved in collagen biosynthesis. Collagen is the major structural component of skin and tissues and is responsible for their resistance. In our bodies it tends to fragment over the years, leaving tissues some visible signs such as loss of elasticity. It is therefore useful to supplement collagen in order to stimulate its own synthesis by the body. This can be achieved by providing the correct amino acid pool via the most bioavailable form that is represented by collagen peptides. In fact, these contain 18 amino acids including the 8 essential ones, and are rich in glycine, proline and hydroxyproline. These last ones make up about 50 percent of collagen peptides and determine different functions. GELITA Bioactive Collagen Peptides (BCP) are a composition of different specific peptides optimized for specific physiological benefits. The peptides are derived from a highly controlled production process of collagen which is determined by hydrolyzation conditions, that permittes the absorption of 95% of the product in the first 12 hours. As a result, GELITA Bioactive Collagen Peptides differ in physiological functionality. They are optimized to maximize stimulation of the human cell types involved in collagen biosynthesis.
The effect of collagen peptides on increased extracellular matrix synthesis is based on two mechanisms:
- Supply of typical collagen amino acids as valuable building blocks,
- Stimulate cell synthesis.
GELITA’s Fortigel® is an innovative ingredient for the regeneration of joint cartilage. Collagenous protein makes up nearly 70% of cartilage mass. Optimized specific collagen peptides of Fortigel® have been proven to activate the growth of new cartilage by stimulating cells helping to make the joints smooth and mobile. By keeping people physically active and mobile, Fortigel® demonstrates itself capable of an improvement in the quality of life. The effectiveness of Fortigel® has been scientifically researched in numerous studies. According to published research, orally administered Fortigel® is absorbed intestinally and accumulates in cartilage. The ingestion of Fortigel® stimulates a statistically significant increase of cartilage tissue metabolism.
A mono centric, placebo-controlled, randomized, double-blind, observational trial on 160 subjects at the Institute for Sports and Sports Science, University of Freiburg, Germany study, investigated the effect of orally administered Bioactive Collagen Peptides on young adults suffering from diagnosed activity-related knee joint pain. In the study a daily dosage of 5g Fortigel® or a placebo was orally administered for 12 duration of weeks. After 3,6 and 12 weeks changes in pain, stiffness and physical function were evaluated in the Fortigel® group using the Western Ontario McMaster Universities Index score (WOMAC). The results of the study clearly demonstrated the efficacy of 5g Fortigel® daily intake. After only 3 weeks of oral administration of the product a statistically significant improvement in pain, stiffness and physical function could be observed. Moreover, this positive effect of Fortigel® persisted and even more pronounced after 6 and 12 weeks of treatment. At the same time secondary treatments such as massage and physiotherapy have been substantially reduced. The increased mobility was accompanied by a statistically significantly reduction in stiffness and a clear pain relief. In more than 40% of all patients a complete pain reduction was achieved and in 70% a positive effect of the therapy could be demonstrated.
An additional component of R-GEN JOINT + is ROXLOR's Cynatine® FLX that can stimulate the production of powerful antioxidants such as glutathione which defend the body from free radicals and tissues from damage. Cynatine ® FLX is a form of hydrolysed keratin, an important source of amino acids and mostly of sulphur, used for the construction and repair of many tissues. It has a fundamental role for structures such as hair and nails and equally for those of proteoglycans. Thanks to its participation in the formation of disulphide bridges, which link amino acids together, it helps determine the shape, properties and biological activity of proteins. Cynatine® FLX can supply cells with antioxidant directly, where they can act against ROS (Reactive Oxigen Species) and prevent oxidative damage.
Accordind to the clinical studies, Cynatine® FLX works in 4 ways:
1. Cynatine® FLX builds joint resilience: it supplies the key building blocks for joint repair. It provides the essential bioactive sulfur precursors that cells use to rebuild vital joint tissue, faster. It is the only joint mobility product that contains the building blocks needed for joint repair and remodeling of tissue.
2. Cynatine® FLX helps reduce inflammation: it suppresses the inflammatory mediators associated with degradation of the joints. A long term inflammation can lead to further erosion and assault on the joint. Reduced inflammation also means reduced pain and increased activity.
3. Cynatine® FLX improves mobility: it activates highly potent antioxidants in the body. Unlike others antioxidants, Cynatine® FLX, is able to quench millions of free radicals with only one molecule of antioxidant agent. It also increases the production of SOD (superoxide dismutase) and of glutathione, a major antioxidant present in all parts of our organism. Research data indicates that ingested Cynatine® FLX helps to build the cell’s glutathione supply, resulting in an increase in glutathione-dependent peroxidase (GSH-PX), which is a primary defense against oxidative damage.
4.Cynatine® FLX protects the joint: it has intrinsic natural antioxidant activity. Even when it is not involved in rallying the body’s own defenses, Cynatine® FLX is still exerting a potent antioxidant effect. By increasing antioxidant defenses, Cynatine® FLX, can reduce the damage in joints caused by free radicals, which cause oxidative stress. This suppresses the inflammatory response which ultimately results in pain reduction and increased mobility.
Finally, the formulation of R-GEN JOINT +, offers vitamin C. Powerful antioxidant and adjuvant of the immune system, it is a great ally for our body wellbeing.
|For serving||7g (one sachet)|