A product based on diosmin and flavonoids of the µSMIN® Plus brand, centella, nettle, red vine and magnesium, for the support of the microcirculation. It has anti-oedematous, anti-inflammatory and antivaricose properties and is useful to fight capillary fragility, varicose veins, hemorrhoids, cellulite and to treat symptoms of venous insufficiency such as nocturnal cramps and pain, heaviness and swelling in the legs.


Diosmin is a flavonoid contained in citrus fruits and fruits of plant species of the Rutaceae family. At venous level it can increase the tone of the walls and plays an anti venous stasis action, while at microcirculation level, it increases the resistance of the capillaries and normalizes their permeability making them less fragile. It acts on red blood cells by reducing their rigidity and aggregation, thus promoting the flow of blood in very small vessels. The protective effect of diosmin towards vascular damage is also shown by inhibiting the release of inflammation mediators such as prostaglandins, free radicals and cytokines.


Several in vivo animal studies have demonstrated the ability of diosmin to also increase lymphatic drainage, a particularly beneficial effect for oedemas (Labrid, 1995). This is due to the increase in both amplitude and frequency of contractions in capillaries. Increased peristalsis leads to an increase in flow and thus in lymphatic flow. According to the research carried out, these activities seem to be attributable to the sodium-potassium pump and calcium channels, which intervene in the automatism of muscle contraction.

VENA DREN+ contains µSMIN® Plus, a flavonoid complex (90%) with a high content of standardized micronized diosmin (90%), which is the most bioavailable form of diosmin on the market today. Diosmin consists of a disaccharide (rutinoside) and the diosmetin aglycone.



After oral administration, diosmin is hydrolyzed in the intestine by enzymes in its diosmetin aglycone, which in turn is absorbed by the intestinal mucosa. The amount of diosmetin in the blood after a single oral diosmin dose is low and highly variable. According to the literature, plasma concentration increases marginally if the diosmin administered is in micronized form. Micronization is a widely used technique that involves the reduction in particle size (1-3μm) by mechanical grinding (jet milling, ball milling, pin milling). The small size of the particles allows improving the bioavailability of a poorly soluble substance, thanks to the increase in the dissolution rate and the increase in the surface of the intestinal contact epithelium.



 WHY μSMIN® Plus? 

A study conducted on μSMIN® Plus showed that after oral administration, the active form of diosmin is rapidly absorbed into the intestine and may remain in circulation for a longer period of time, thus prolonging its biological effect. The higher plasma concentration of μSMIN® Plus compared to that of standardised micronized diosmin also suggests better absorption in the intestine. It has been discovered that the bioavailability of μSMIN® Plus is far greater (about 400%) than standardised micronized diosmin, which also suggests that a smaller dose is needed to achieve the same biological effects. μSMIN® Plus has a better pharmacokinetic profile than conventional micronized diosmin, resulting in an excellent element against CVI (chronic venous insufficiency), hemorrhoids, varicose veins and to improve microcirculation and vascular trophism in general.

Experimental evidence shows that diosmin solubility is influenced by the pH, being low in neutral or acid solutions and higher in alkaline solutions. For this reason, in addition to the fine micronization that it already has, μSMIN® Plus is provided with a buffer system that promotes the transformation of the glycosidic form into agliconic form (diosmetin) in the intestine.

μSMIN® Plus is a highly technological and innovative product, the result of careful scientific research that, thanks to its characteristic formulation, is quickly absorbed and highly bioavailable. Also present in the formulation of VENA DREN+ is Centella (Centella asiatica (L.) Urb.). Adopted by Ayurvedic medicine, it is known for its positive action on blood circulation and in particular for its protective action on capillaries. Rich in flavonoids, tannins and triterpenes, it has a predominantly phlebotonic action. It can increase the elasticity of the blood vessel walls avoiding collapsing and relaxation, thus promoting proper peripheral circulation. Thanks to the active ingredients it contains, it can stimulate the production of collagen by protecting the blood vessel walls, keeping them toned and supple to combat their fragility. It is useful in cases of chronic venous insufficiency (CVI), edematous swelling of the legs and feet, cellulite and hemorrhoids, due to the weakness of the venous wall. Vitis vinifera supports these actions thanks to the contribution of the flavonoids it contains and the additional support given by proanthocyanidins, responsible for stabilizing the collagen of the vessel wall. These in fact have high antioxidant power, useful for the microcirculation and blood circulation.

To support the actions of diosmin and centella, VENA DREN+ combines in its formula an ancient phytotherapeutic remedy with proven effectiveness over the years: the nettle (Nettle dioecious, fam. Urticaceae). It is a plant whose leaves are rich in flavonoids, the same substances that we have seen have a powerful action at microcirculation level and in particular on capillaries. Nettle is an excellent support for the vessel walls, is rich in iron and has an excellent draining power. Effective property against water retention and swelling of the feet and legs caused by the reduced elasticity of the vessels.

Magnesium completes the formulation of VENA DREN+. An element present in multiple reactions within the body and also involved in the balance of some electrolytes, whose concentrations affect the efficiency of the lymphatic system. Its deficiency can lead to the accumulation of waste in the interstitial liquids, causing the much feared water retention.

μSMIN® Plus is a registered trademark of Giellepi S.p.A.

How to use
Take 2 tablets per day, one in the morning and one in the evening.
Ingredients - Nutritional Info
Bulking agent: microcrystalline cellulose; µSMIN® Plus (flavonoids complex 90%, micronized diosmin 80%), magnesium citrate, centella (Centella asiatica (L.) Urb.) aerial part d.e. 20% total triterpene derivatives, nettle (Urtica dioica L.) leave d.e, red grape (Vitis vinifera L.) seed d.e. 95% proanthocyanidins; anti-caking agents: magnesium salts of fatty acids, silicon dioxide.

Additional Information

For serving 2 tab
µSMIN® Plus 500 mg
- of which flavonoids complex 450 mg
- of which diosmin 400 mg
Centella d.e. 200 mg
- of which total diterpene derivates 40 mg
Nettle leave d.e. 150 mg
Red grape d.e. 105 mg
- of which pranhocyanidins 100 mg
Magnesium 56 mg
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Available Product code VENA-DREN


A product based on diosmin and flavonoids of the µSMIN® Plus brand, centella, nettle, red vine and magnesium, for the support of the microcirculation. It has anti-oedematous, anti-inflammatory and antivaricose properties and is useful to fight capillary fragility, varicose veins, hemorrhoids, cellulite and to treat symptoms of venous insufficiency such as nocturnal cramps and pain, heaviness and swelling in the legs.

Normal Day

  • morning
  • lunch
  • afternoon
  • dinner
  • night